Oryzon Genomics

Oryzon Genomics SA is a Spain-based biopharmaceutical company. It is engaged in the field of epigenetic medicine and in the development of therapeutic, biological solutions for cancer and neurodegenerative diseases. The Company's business model focuses on identifying biomarkers that can be translated in new therapeutic targets, as well as on investing in programs, mainly through the development of small molecules for two main indications: cancer and neurodegeneration. The Company develops investigational medicines till proof of concept (POC) phase and then partners the program with pharmaceutical entities, which are able to get the approval from drug agencies to bring these medicines to the patients. It cooperates with Roche. The Company is a subsidiary of Laboratorio Reig Jofre SA.
  • TickerORY
  • ISINES0167733015
  • ExchangeMadrid Stock Exchange
  • SectorPharmaceuticals & Biotechnology
  • CountrySpain

Analysts

Dr Jonas Peciulis

Oryzon Genomics - A year of data readouts

Oryzon has a total of five Phase II studies ongoing with its two lead assets iadademstat (formerly ORY-1001) and vafidemstat (formerly ORY-2001), which are all expected to have preliminary data readouts in 2019. In November 2018, the company announced the first patients had been recruited in to the iadademstat Phase IIa small cell lung cancer (CLEPSIDRA) and acute myeloid leukaemia (ALICE) studies. A scientific paper was recently published by a third party in Science Signalling, which has revealed a potential mechanism of action of iadademstat (ORY-1001) in pre-clinical SCLC models; this is su...

Olga Smolentseva ...
  • Thibaut Voglimacci-Stephanopoli

INVEST SECURITIES - ORYZON GENOMICS : More action in Idademstat's mechanism of action

Dr Jonas Peciulis

Oryzon Genomics - A year of data readouts

Oryzon has a total of five Phase II studies ongoing with its two lead assets iadademstat (formerly ORY-1001) and vafidemstat (formerly ORY-2001), which are all expected to have preliminary data readouts in 2019. In November 2018, the company announced the first patients had been recruited in to the iadademstat Phase IIa small cell lung cancer (CLEPSIDRA) and acute myeloid leukaemia (ALICE) studies. A scientific paper was recently published by a third party in Science Signalling, which has revealed a potential mechanism of action of iadademstat (ORY-1001) in pre-clinical SCLC models; this is su...

Olga Smolentseva ...
  • Thibaut Voglimacci-Stephanopoli

INVEST SECURITIES - ORYZON GENOMICS : More action in Idademstat's mechanism of action

Dr Jonas Peciulis

Oryzon Genomics - Ramping up R&D activity; catalysts in 2019

The €13m (gross) private placement announced on 30 October 2018 will support Oryzon’s expanding R&D programme with a total of five clinical trials now underway. Two new Phase IIa trials with iadademstat (formerly ORY-1001) are starting in acute myeloid leukaemia (AML) (ALICE trial) and small cell lung cancer (SCLC) (CLEPSIDRA trial). Results from another two Phase IIa studies with vafidemstat (formerly ORY-2001) in Alzheimer’s disease (AD) patients (ETHERAL) and multiple sclerosis (MS) patients (SATEEN) are due to report results in H219. Before that, interim results from the innovative design ...

Martial Descoutures ...
  • Thibaut Voglimacci-Stephanopoli

INVEST SECURITIES - Oryzon Genomics : Une nouvelle vague - ACHAT ; OC 9.3€

Nous initions ce matin la couverture avec une opinion ACHAT et un objectif de cours de 9,3€. ORYZON est une Biotech espagnole spécialisée dans les traitements de cancers ou de troubles neurodégénératifs. Basés sur sa plateforme épigénétique (système de régulation contrôlant l'expression des gènes), les deux produits phares du groupe ORY1001 et ORY2001 sont actuellement en phase IIa dans 4 indications : Alzheimer, Sclérose en plaques, SCLC et la LAM. Les premiers résultats intermédiaires sont attendus mi 2019.

Dr Jonas Peciulis

Oryzon Genomics - Awaiting for eventful 2019

The next year is shaping up to be transformative for Oryzon with two data readouts from Phase IIa trials with ORY-2001 in Alzheimer’s disease (AD) and multiple sclerosis (MS). In addition, an innovative design basket trial with ORY-2001 in several neuropsychiatric disorders may also deliver first results next year. Oryzon is resuming the development of ORY-1001 in acute myeloid leukaemia (AML) and small-cell lung cancer (SCLC). While Roche’s departure was a setback in 2017, the stars started to align again after the Biogen Abeta antibody data provided a much-needed boost for AD research indust...

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